diff --git a/news/5299.bugfix.rst b/news/5299.bugfix.rst
new file mode 100644
index 00000000..3e724299
--- /dev/null
+++ b/news/5299.bugfix.rst
@@ -0,0 +1 @@
+Sorting ``constraints`` before resolving, which fixes ``pipenv lock`` generates nondeterminism environment markers.
diff --git a/pipenv/utils/resolver.py b/pipenv/utils/resolver.py
index 198ad484..82663b68 100644
--- a/pipenv/utils/resolver.py
+++ b/pipenv/utils/resolver.py
@@ -647,6 +647,7 @@ class Resolver:
             # Only use default_constraints when installing dev-packages
             if self.dev:
                 self._constraints += self.default_constraints
+            self._constraints.sort(key=lambda ireq: ireq.name)
         return self._constraints
 
     @contextlib.contextmanager