diff --git a/requests/models.py b/requests/models.py
index 7d3b1c82..1dd9b489 100644
--- a/requests/models.py
+++ b/requests/models.py
@@ -517,9 +517,10 @@ class Request(object):
             self.headers['Content-Type'] = content_type
 
         _p = urlparse(url)
+        no_proxy = filter(lambda x:x.strip(), self.proxies.get('no', '').split(','))
         proxy = self.proxies.get(_p.scheme)
 
-        if proxy:
+        if proxy and not any(map(_p.netloc.endswith, no_proxy)):
             conn = poolmanager.proxy_from_url(proxy)
             _proxy = urlparse(proxy)
             if '@' in _proxy.netloc: