diff --git a/requests/models.py b/requests/models.py
index bbf08c81..a6af6427 100644
--- a/requests/models.py
+++ b/requests/models.py
@@ -655,8 +655,12 @@ class Response(object):
 
             self._content_consumed = True
 
-        # simulate reading small chunks of the content
-        reused_chunks = iter_slices(self._content, chunk_size)
+        if self._content_consumed and isinstance(self._content, bool):
+            raise RuntimeError(
+                        'The content for this response was already consumed')
+        else:
+            # simulate reading small chunks of the content
+            reused_chunks = iter_slices(self._content, chunk_size)
 
         stream_chunks = generate()